Acupuncture ivf research, Acupuncture Research, Fertility, Women's health
Am J Physiol Endocrinol Metab. 2013 May 1;304(9):E934-43. doi: 10.1152/ajpendo.00039.2013. Epub 2013 Mar 12.
Johansson J1, Redman L, Veldhuis PP, Sazonova A, Labrie F, Holm G, Johannsson G, Stener-Victorin E.
Abstract
Acupuncture has been demonstrated to improve menstrual frequency and to decrease circulating testosterone in women with polycystic ovary syndrome (PCOS). Our aim was to investigate whether acupuncture affects ovulation frequency and to understand the underlying mechanisms of any such effect by analyzing LH and sex steroid secretion in women with PCOS. This prospective, randomized, controlled clinical trial was conducted between June 2009 and September 2010. Thirty-two women with PCOS were randomized to receive either acupuncture with manual and low-frequency electrical stimulation or to meetings with a physical therapist twice a week for 10-13 wk. Main outcome measures were changes in LH secretion patterns from baseline to after 10-13 wk of treatment and ovulation frequency during the treatment period. Secondary outcomes were changes in the secretion of sex steroids, anti-Müllerian hormone, inhibin B, and serum cortisol. Ovulation frequency during treatment was higher in the acupuncture group than in the control group. After 10-13 wk of intervention, circulating levels of estrone, estrone sulfate, estradiol, dehydroepiandrosterone, dehydroepiandrosterone sulfate, androstenedione, testosterone, free testosterone, dihydrotestosterone, androsterone glucuronide, androstane-3α,17β-diol-3-glucuronide, and androstane-3α,17β-diol-17-glucuronide decreased within the acupuncture group and were significantly lower than in the control group for all of these except androstenedione. We conclude that repeated acupuncture treatments resulted in higher ovulation frequency in lean/overweight women with PCOS and were more effective than just meeting with the therapist. Ovarian and adrenal sex steroid serum levels were reduced with no effect on LH secretion.
Acupuncture Research
Am J Chin Med. 2018 Oct 9:1-33. doi: 10.1142/S0192415X18500738.
Wang H1,2, Yang G3, Wang S4,2, Zheng X5,2, Zhang W6, Li Y2.
Author information
1 * School of Medicine, Shanghai Jiaotong University, Shanghai, P. R. China.
2 ∥ American TCM Society, New York City, New York, USA.
3 † Department of Specialty Medicine, Ohio University, Athens, Ohio, USA.
4 ‡ New York Acupuncture & Chinese Herbs Clinic, New York City, New York, USA.
5 § Pacific College of Oriental Medicine, New York City, New York, USA.
6 ¶ Center for Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Abstract
Acupuncture has been a popular alternative medicine in the United States for several decades. Its therapeutic effects on pain have been validated by both basic and clinical researches, and it is currently emerging as a unique non-pharmaceutical choice for pain against opioid crisis. However, the full spectrum of acupuncture indications remains unexplored.In this study, we conducted a cross-sectional survey among 419 acupuncturists nation-wide to investigate the top 10 and top 99 acupuncture indications in private clinics in the United States.We found the top 10 indications to be:lower back pain, depression, anxiety, headache, arthritis, allergies, general pain, female infertility, insomnia, neck pain and frozen shoulder.Among the top 99 indications, pain represents the largest category; and mental health management, especially for mood disorders, is in greatest demand.The following popular groups are: immune system dysfunctions, gastrointestinal diseases, gynecology and neurology. In addition, specialty index, commonality index, and the potential to become medical specialties were estimated for each indication. Demographic analysis suggests that China trained acupuncturists tend to have broader indication spectrums, but the top conditions treated are primarily decided by local needs. Also, gender, resident states, age and clinical experience all affect indication distributions.Our data for the first time outlines the profile of acupuncture treatable conditions in the US and is valuable for strategic planning in acupuncture training, healthcare administration and public education.
Acupuncture Research, Acupuncture ivf research, Fertility, IVF acupuncture, Men's health, Women's health
Compiled from Journals, Internet, and Website resources as a tool to aid ABORM members understand the depth and breadth of Western Style research related to our fields.
Worked completed by: Diane K. Cridennda, L.Ac., FABORM, Member Board of Directors Founder/Owner: East Winds Acupuncture
Acupuncture ivf research, Fertility, Men's health
He Y, Chen CT, Qian LH, Xia CL, Li J, Li SQ, Liu BP.
Objective
To systematically evaluate acupuncture as a treatment for male infertility.
Methods
We searched Chi na Biology Medical Database (CBM), Wan Fang Medical Information System, China National Knowledge Infrastructure (CNKI), VIP Information Resource System (VIP), and PubMed for published literature on acupuncture as a treatment for male infertility on May 1 2014. Based on the Standards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA), we evaluated the quality of the reports, conducted meta-analysis on the identified studies via RevMan5.2, and assessed the quality of the evidence in the literature by Grading of Recommendations Assessment, Development, and Evaluation (GRADE).
Results
A total of 12 studies involving 2,177 patients were included, the quality of which was evaluated as mediocre. With regard to the cure rate, acupuncture was comparable to traditional Chinese medicine (TCM) (P > 0.05) but better than Western medicine (RR = 4.00, 95% CI 1.63 to 9.82, P < 0.01) while acupuncture + TCM was better than either TCM (RR = 1.77, 95% CI 1.20 to 2.60, P < 0.01) or Western medicine used alone (RR = 2.73, 95% CI 1.51 to 4.93, P < 0.01), and acupuncture + Western medicine was better than Western medicine alone (RR = 1.88, 95% CI 1.17 to 3.02, P = 0.01). The combined use of acupuncture, ear pressure, TCM, and Western medicine showed a higher cure rate than the combination of TCM and Western medicine (RR = 3.45, 95% CI 2.90 to 4.11, P < 0.01). In therapeutic effectiveness, acupuncture was comparable to TCM (P > 0.05) but superior to Western medicine (RR = 1.41, 95% CI 1.12 to 1.71, P < 0.01), acupuncture + TCM was superior to either TCM (RR = 1.14, 95% CI 1.05 to 1.23, P < 0.01) or Western medicine alone (RR = 1.43, 95% CI 1.22 to 1.67, P < 0.01), and acupuncture + Western medicine was superior to Western medicine alone (RR = 1.25, 95% CI 1.05 to 1.49, P = 0.01). In improving sperm concentration, acupuncture was as effective as TCM (P > 0.05) and sham acupuncture (P > 0.05) but outdid Western medicine (RR = 27.00, 95% CI 24.27 to 29.73, P < 0.01) and acupuncture + TCM outdid either TCM (RR = 14.65, 95% CI 7.58 to 21.72, P < 0.01) or Western medicine alone (RR = 1.04, 95% CI–1.43 to 3.51, P > 0.05). In improving grade a sperm, acupuncture exhibited a similar effect to TCM (P > 0.05) and sham acupuncture (P > 0.05), and acupuncture + TCM was more effective than TCM alone (RR = 7.78, 95% CI 3.51 to 12.23, P < 0.01) but equally effective as Western medicine (P > 0.05). In elevating the level of grade a + b sperm, acupuncture + TCM excelled either TCM (RR = 11.00, 95%, CI 3.17 to 18.82, P < 0.01) or Western medicine alone (RR = 12.22, 95% CI 6.87 to 17.57, P < 0. 01), while acupuncture produced a comparable effect with sham acupuncture (P > 0.05). As for the quality of the included studies, only 3 conclusions of the 23 meta-analyses were assessed to be of average quality, while the others of poor or extremely poor quality. Therefore, the recommendation grade of the conclusions was low.
Conclusion
For the treatment of male infertility, acupuncture is reported to be equally effective as TMC and more effective than Western medicine, and its effectiveness is enhanced when applied in combination with either TCM or Western medicine. Acupuncture is distinctively efficacious in improving sperm quality. Nevertheless, the overall quality of the included studies is low.
Acupuncture Research, Acupuncture ivf research, Men's health
Influence of acupuncture on idiopathic male infertility in assisted reproductive technology
J Huazhong Univ Sci Technolog Med Sci. 2002;22(3):228
Zhang M, Huang G, Lu F, Paulus WE, Sterzik K.
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030.
The clinical effects of acupuncture on idiopathic male infertility in sperm parameter and on therapeutic results in assisted reproductive technology were investigated. 22 patients failed in intracytoplasmic sperm injection (ICSI) with idiopathic male infertility were treated with acupuncture twice weekly for 8 weeks, followed by ICSI treatment again. The sperm concentration, motility, morphology, fertilization rates and embryo quality were observed. Quick sperm motility after acupuncture (18.3% +/- 9.6%) was significantly improved as compared with that before treatment (11.0% +/- 7.5%, P < 0.01). The normal sperm ratio was increased after acupuncture (21.1% +/- 10.4% vs 16.2% +/- 8.2%,P < 0.05). The fertilization rates after acupuncture (66.2%) were obviously higher than that before treatment (40.2%, P < 0.01). There was no significant difference in sperm concentration and general sperm motility between before and afteracupuncture. The embryo quality after acupuncture was improved, but the difference between them was not significant (P > 0.05). Acupuncture can improve sperm quality and fertilization rates in assisted reproductive technology.
PMID: 12658811 [PubMed-indexed for MEDLINE]
Does acupuncture treatment affect sperm density in males with very low sperm count? A pilot study
Andrologia Volume 32 Issue 1 Page 31 January 2000
S. Siterman, F. Eltes, V. Wolfson, H. Lederman & B. Bartoov
Classic therapies are usually ineffective in the treatment of patients with very poor sperm density. The aim of this study was to determine the effect of acupuncture on these males. Semen samples of 20 patients with a history of azoospermia were examined by light microscope (LM) and scanning electron microscope (SEM), with which a microsearch for spermatozoa was carried out. These examinations were performed before and 1 month after acupuncture treatment and revealed that the study group originally contained three severely oligoteratoasthenozoospermic (OTA), two pseudoazoospermic and 15 azoospermic patients. The control group was comprised of 20 untreated males who underwent two semen examinations within a period of 24 months and had initial andrological profiles similar to those of the experimental group. No changes in any of the parameters examined were observed in the control group. There was a marked but not significant improvement in the sperm counts of severely OTA males following acupuncture treatment (average=0.7±1.1 10 6 spermatozoa per ejaculate before treatment vs. 4.3±3.2 10 6 spermatozoa per ejaculate after treatment). A definite increase in sperm count was detected in the ejaculates of 10 (67%) of the 15 azoospermic patients. Seven of these males exhibited post-treatment spermatozoa that were detected even by LM. The sperm production of these seven males increased significantly, from 0 to an average of 1.5±2.4 10 6 spermatozoa per ejaculate (Z= 2.8, P <0.01). Males with genital tract inflammationexhibited the most remarkable improvement in sperm density (on average from 0.3±0.6 106 spermatozoa per ejaculate to 3.3±3.2 10 6spermatozoa per ejaculate; Z=2.4, P 0.02). Two pregnancies were achieved by the IVF-ICSI procedure.It is concluded thatacupuncture may be a useful, nontraumatic treatment for males with very poor spermdensity, especially those with a history of genital tract inflammation.
Modification of semen quality by acupuncture in subfertile males
[Article in German]
Geburtshilfe Frauenheilkd. 1984 Aug;44(8):510
Fischl F, Riegler R, Bieglmayer C, Nasr F, Neumark J.
Our first attempt in treating subfertility by acupuncture was carried out on 28 males. The results obtained from the experiences in veterinary medicine encouraged us to attempt this type of therapy. Each patient received a total of 10 treatments for a period of three weeks. Several spermiograms were made afterdiagnosis subfertility. We checked spermiograms and hormone levels before and after acupuncture. Total count, concentration and motility were evaluated. In all cases we observed a statistically significant improvement of sperm quality. Having obtained these good results in our first studies, we now intend to continue acupuncture therapy in subfertile males for insemination or intercourse at the time of the ovulation of their female partners.
PMID: 6566639 [PubMed-indexed for MEDLINE]
Acupuncture Research, Fertility
Ovarian deficiency, including primary ovarian insufficiency (POI) and premature ovarian failure, can significantly impact fertility and overall hormonal health. A recent study published in Evidence-Based Complementary and Alternative Medicine has provided promising evidence that electroacupuncture (EA) may help regulate reproductive hormone levels in women with ovarian deficiency.
Key Findings of the Study
Researchers investigated how electroacupuncture influences hormone levels in women with POI. The study included 11 participants who underwent EA treatment following this regimen:
- Five sessions per week for the first four weeks
- Three sessions per week for the next two months
- A three-month follow-up period
Hormonal Changes Observed:
- Increased estrogen (E2) levels – Essential for menstrual cycle regulation and fertility
- Decreased follicle-stimulating hormone (FSH) levels – High FSH often indicates ovarian insufficiency
- Decreased luteinizing hormone (LH) levels – Important for ovulation and hormonal balance
These hormonal improvements persisted even after the treatment ended, suggesting long-term benefits of acupuncture for ovarian function.
Menstrual Cycle Restoration
One of the most remarkable outcomes was that 10 out of 11 women (90.91%) resumed menstruation after acupuncture treatment. This suggests that acupuncture may help restore natural ovarian activity in women with POI.
Safety and Side Effects
Acupuncture was well-tolerated, with only mild temporary pain reported in some cases. No serious adverse effects were observed, making it a safe option for women seeking natural approaches to ovarian health.
What This Means for Women with Ovarian Deficiency
This study supports the growing body of evidence that Traditional Chinese Medicine (TCM), including acupuncture, may offer a natural and effective approach to managing POI. While more extensive research is needed, acupuncture has already shown promising results in reducing FSH and LH levels while improving estrogen levels.
http://www.ncbi.nlm.nih.gov/pubmed/23533511
Acupuncture Research
Levett KM, et al., Complementary Therapies in Medicine, 06/17/2014
Results
The RCTs included in these systematic reviews differed in terms of study designs, research questions, treatment protocols and outcome measures, and yielded some conflicting results. It may be inappropriate to include these together in a systematic review, or pooled analysis, of acupuncture for labour with an expectation of an overall conclusion for efficacy. Trials of acupuncture and acupressure in labour show promise, but further studies are required.The aim of this study is to examine current evidence from systematic reviews on the topic of acupuncture and acupressure for pain management in labour and birth, and to evaluate the methodological and treatment frameworks applied to this evidence. The use of current systematic reviews of the evidence for acupuncture and acupressure for labour and birth may be misleading. Appropriate methods and outcome measures for investigation of acupuncture and acupressure treatment should more carefully reflect the research question being asked, the use of pragmatic trials designs with woman–centred outcomes may be appropriate for evaluating the effectiveness of these therapies.
Methods
A search limited to systematic reviews of the MEDLINE, CINAHL, PUBMED, EMBASE and Cochrane databases was performed in December 2013 using the keywords ‘CAM’, ‘alternative medicine’, ‘complementary medicine’, ‘complementary therapies’, ‘traditional medicine’, ‘Chinese Medicine’, ‘Traditional Chinese Medicine’, ‘acupuncture’, ‘acupressure’, cross–referenced with ‘childbirth’, ‘birth’, labo*r’, and ‘delivery’.The quality of the evidence is also evaluated in the context of study design.
Acupuncture Research
A recent study, “Acupuncture Relieves the Excessive Excitation of Hypothalamic-Pituitary-Adrenal Cortex Axis Function and Correlates with the Regulatory Mechanism of GR, CRH, and ACTHR,” has revealed promising findings about how acupuncture can help manage stress.
Led by Dr. S.J. Wang, this research, published in the journal Evidence-Based Complementary and Alternative Medicine (Volume 2014, Article ID 495379), explores how acupuncture affects the body’s stress response.
Understanding Stress
Stress is a common issue that affects both physical and mental health. The hypothalamic-pituitary-adrenal cortex axis (HPAA) is crucial in how our body responds to stress. While previous research suggested acupuncture could calm the overactive HPAA, the specific effects on glucocorticoid receptors (GR) were unclear until now.
Study Goals
The main goal of this study was to see how acupuncture changes the protein levels of key stress-related components in the HPAA, including corticotrophin releasing hormone (CRH), adrenocorticotropic hormone receptor (ACTHR), and GR, both in normal and stressed conditions.
Key Findings
The study found some fascinating ways acupuncture affects stress:
Under Stress:
- Acupuncture increased GR protein in the brain’s hippocampus and hypothalamic paraventricular nucleus (PVN), and in the pituitary gland.
- It reduced GR protein in the adrenal cortex, leading to lower glucocorticoid (GC) production, a major stress hormone.
- Acupuncture decreased CRH and ACTHR protein levels, reducing the stress response.
Under Normal Conditions:
- Acupuncture boosted GR protein in the hippocampus and CRH in the hippocampus and PVN.
Conclusion
The study suggests acupuncture helps manage stress by improving the interaction between GCs and GR, which affects GR protein levels. This interaction creates a feedback loop that reduces CRH and ACTHR over-expression, lowering GC levels and GR protein in the adrenal cortex.
These groundbreaking findings bring us closer to understanding how acupuncture can be a powerful tool for stress relief. For a deeper dive into the study, check out the full article in Evidence-Based Complementary and Alternative Medicine.
