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Recurrent miscarriage–outcome after supportive care in early pregnancy

coverLiddell HS et al, Aust N Z J Obstet Gynaecol. 1991 Nov;31(4):320-2.

This study did not use acupuncture or herbs, but it is interested to include it here as a way of managing early pregnancy in women who have had previous miscarriages. There is currently no known prevention therapy for unexplained recurrent miscarriage, but this study showed that emotional support and close supervision helped improve outcomes in subsequent pregnancies.

Abstract

One hundred and thirty three couples were investigated at a recurrent miscarriage clinic. In their next pregnancy 42 women (Group 1) with unexplained recurrent miscarriage were managed with a programme of formal emotional support and close supervision at an early pregnancy clinic. Two women were seen in 2 pregnancies (44 supervised pregnancies); 86% (38 of 44) of these pregnancies were successful. Four of the 6 miscarriages had an identifiable causal factor. Nine women (Group 2), also with unexplained recurrent miscarriage, acted as a control group. After initial investigation they were reassured and returned to the care of their family practitioner and did not receive formal supportive care in their subsequent pregnancy; 33% (3 of 9) of these pregnancies were successful (p = 0.005; Fishers Exact Test). Whilst acknowledging that there is a significant spontaneous cure rate in this condition, emotional support seems to be important in the prevention of unexplained recurrent miscarriage, giving results as good as any currently accepted therapy.

Effect of Quyu Jiedu Granule (祛瘀解毒颗粒) on Micro environment of Ova in Patients with Endometriosis

Lian Fang et al, Zhong Xi Yi He Xue Bao 2009 Feb;15(1):42-46 Chinese Journal of Integrated Medicine

A chinese herb formula for endometriosis was given to women with  long term infertility and endometriosis before and during an IVF cycle and various ovarian parameters were compared with a group of women with endometriosis who embarked on IVF directly without taking the herbs. The group who took the herbs produced more eggs and had a higher fertilisation rate (although a difference in pregnancy rate was not reported). Additionally the follicles of the women who took the herbs showed a reduced level of inflammatory cytokines compared to the women in the control group.

Abstract

Objective

To observe the effect of Quyu Jiedu Granules (QJG) on the microenvironment of ova in patients with endometriosis (EM).

Methods

Twenty EM patients who received in vitro fertilization and embryo transfer (IVF-ET) were randomized equally into a treated group and a control group.Further, 20 patients who received IVF-ET due to oviduct factors were enrolled into a non-endometriosis group.The dosage of gonadotrophic hormone used, the number of ova attained, fertilization rate and clinical pregnancy rate were all observed, and the levels of tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) in follicular fluid as well as their mRNA expressions in ovarian granular cells were detected by RT-PCR on the very day of ovum attainment.

Results

The ova attainment (13.80±6.87) and fertilization rate (0.69±0.31) in the treated group were all higher than the corresponding values in the control group (9.80±5.32 and 0.47±0.22); the follicular fluid contents of TNF-α and IL-6 in the treated group were 1.38±0.21 ng/mL and 130.56±12.81 pg/mL, respectively, which were lower than those in the control group (1.98±0.34 ng/mL and 146.83±17.65 pg/mL, respectively). Further, the treated group showed much lower mRNA expressions of TNF-α and IL-6 in ovarian granular cells.

Conclusions

The elevation of TNF-α and IL-6 contents in follicular fluid and their mRNA expressions in ovarian granular cells are possibly related to the low quality of ova in EM; QJG might raise the ova quality by reducing TNF-α and IL-6 levels to improve the living micro-environment for the ova.

Clinical Observations on the Treatment of Endometriosis by Combined Acupuncture and Herbs

Shanghai Journal of Acupuncture and MoxibustionFu Yu and Xia Tian, Shanghai Jnl Acup Moxa, 2005, Vol 3 Shanghai Journal of Acupuncture and Moxibustion

This is just one trial of many carried out in China which looks at the clinical effectiveness of treatment of endometriosis with acupuncture and Chinese herbs. The investigators report that symptoms  and signs of the disease are treated effectively without side effects.

 

Abstract

Objective

To compare the clinical efficacy of combined acupuncture and herbs with danazol for treatment of endometriosis.

Methods

Seventy-eight patients were randomly divided into a combined acupuncture and herbs treatment group (40 cases) and a Westerm medicine control group (38 cases). Observation was made of changes in clinical symptoms, signs, serum CA 125, β-EP, PGE 2 and PGF 2α, and adverse reaction to the medicine in the two group.

Results

The overall efficacy was similar in the two groups, but the effects on lumbosacral pain, anal downbearing distention, irregular menstruation and infertility were significantly better in the treatment group than in the control group(P < 0.05), and in the treatment group serum CA 125, PGE 2 and PGF 2α were significantly lower and serum β-EP was significanly higher after treatment than before (P < 0.05).

Conclusion

Combined use of acupuncture and herbs has a marked effect on endometriosis and the adverse reaction is lower than the control group.

Clinical Observation of Chinese Medicine Treatment on Secondary Dysmenorrhoea Associated with Endometriosis

Australian Journal of Acupuncture and Chinese Medicine

Australian Journal of Acupuncture and Chinese Medicine

Lim CED et al, Aust J Acupunct Chin Med 2009;4(2):12-17. Australian Journal Acupuncture and Chinese Medicine

Those of us who have experience in treating endometriosis with Chinese medicine are familiar with the benefits it brings patients in terms of reduced pain and possibly increased rates of conception. This pilot study, a collaboration between Guangzhou Medical University in China and RMIT university in Melbourne, is particularly interesting to us since it measured objective parameters such as immune factors (antigens and antibodies) shown to be abnormally raised in patients with endometriosis. A course of treatment with Chinese herbs not only improved pain but significantly reduced the levels of these immune factors. This is one way that Chinese medicine may improve fertility in endometriosis.

 

Abstract

Background

Secondary dysmenorrhoea associated with endometriosis affects many women and is the leading cause of work and school absenteeism, with considerable impact on quality of life. This study evaluates the possible role of Chinese medicinal herbs in relieving the menstrual pain associated with endometriosis.

 

Methods

A prospective clinical observational pilot study involving twenty-five patients with endometriosis with Chinese medical diagnosis of stagnation of qi and blood who were recruited at the Guangdong Women’s and Children’s Hospital during the period of January 2004 to December 2006 to participate in a three-month Chinese medicinal herbs study.

 

Results

Sixteen patients reported nil dysmenorrhoea during the treatment period. The mean CA125 at the study entry was 59.67 ±28.32 u/ml, compared to 34.83 ±16.34 u/ml post-treatment. The positive EMAb before the commencement of treatment was noted in 22 of 25 cases (88%), while 5 of 25 cases (20%) remained positive after treatment.

 

Conclusion

Short-term administration of Chinese medicinal herbs may be effective in alleviating secondary dysmenorrhoea associated with endometriosis in qi and blood stagnation pattern. It may provide an alternative treatment option for the management of pelvic pain associated with endometriosis and further research in the area is required.

ACUPUNCTURE, HERBS AND ENDOMETRIOSIS: Complementary and Alternative Medicine for Endometriosis: A Review of Utilisation and Mechanism

ACUPUNCTURE, HERBS AND ENDOMETRIOSIS: Complementary and Alternative Medicine for Endometriosis: A Review of Utilisation and Mechanism

Evidence-Based-Complementary-and-Alternative-Medicine

Evidence-Based-Complementary-and-Alternative-Medicine

Kong S et al, Volume (2014), Article ID 146383, 16 pages Evidence-Based Comp and Altern Med Evidence-Based Complementary and Alternative Medicine

This very thorough review compares results of treatment of endometriosis with acupuncture or herbal therapies and pharmaceutical or surgical approaches. A number of therapies, including using Chinese herbs per rectum, obtained great relief for patients, but without the side effects caused by drugs or surgery.

Abstract

Endometriosis (EM) is one of the common gynecological conditions causing menstrual and pelvic pain and affects 10%–15% of women of reproductive age. In recent years, the complementary and alternative medical (CAM) treatment for EM has become popular due to the few adverse reactions reported. The CAM therapy for EM includes several different treatments such as herbs (herbal prescription, extract, and patent), acupuncture, microwave physiotherapy, and Chinese herb medicine enema (CHM enema). These CAM therapies are effective at relieving dysmenorrhoea, shrinking adnexal masses, and promoting pregnancy, with less unpleasant side effects when compared to hormonal and surgical treatments. In this review, we focus on the status quo of CAM on EM and try to identify therapeutic efficacy and mechanisms based on some clinical and experimental studies. We hope to provide some instructive suggestions for clinical treatment and experimental research in the future. 

Acupuncture Combined with Herbal Medicine Effects on Outcomes of Patients with Endometriosis Who Accepted IVF-ET

Liaoning Chinese Medicine Journal

Acupuncture & Herbal Medicine Boost IVF Success in Endometriosis Patients

In a study conducted in northeastern China, 180 women diagnosed with endometriosis undergoing IVF treatments were divided into three groups. The study aimed to determine the impact of acupuncture and Chinese herbal medicine on IVF outcomes.

The Findings:

  1. The acupuncture combined with herbal medicine group had notably higher pregnancy rates compared to those who did not receive acupuncture.
  2. Among the three groups undergoing IVF, the one with acupuncture and herbal medicine showed significantly better outcomes in terms of oocyte retrieval, fertilization rates, implantation success, and overall pregnancy rates.
  3. The patients receiving acupuncture combined with herbal medicine reported better satisfaction scores than those only receiving medicine.

Conclusion: The study concludes that the use of acupuncture alongside herbal medicine had a substantial positive impact on IVF outcomes for women with endometriosis. This combined approach proved more effective than solely using medicine during IVF treatments.

针灸治疗哮喘:中医成果登上《Science》子刊封面

揭示针灸治疗哮喘的深层原理

上海中医药大学深入探究针灸治疗哮喘的基本原理,有望开发一种针对背部穴位的新型抗哮喘药物,有效治疗哮喘。但这种传统疗法背后的分子和细胞机制究竟是什么呢?

探索针灸的分子途径

在北京时间2018年2月8日最新一期的《科学转化医学》杂志上,上海中医药大学的杨永清教授及其团队透露了近十年来对抗哮喘靶标和针灸效应的研究取得的突破性进展。

他们的研究不仅通过临床针灸确定了新的有效靶点,还阐明了体内一系列蛋白质反应。此外,他们还发现了能够模拟针灸效果的活性小分子,有望转化为具有广泛应用前景的“针灸药”。

赞誉与认可

《科学》的主编将这些发现称为激发人心和发人深思的创新。这是中国传统医学从业者首次在《科学》专门子刊上发表具有独立知识产权的原创科学工作,也是中国科学家首次确认的新支气管哮喘靶标。

历史视角:传统智慧与现代科学的结合

哮喘是一种常见的呼吸道疾病,常规治疗方法主要包括皮质激素和β2肾上腺素受体激动剂。然而,这些药物不仅有各种副作用,而且容易导致药物耐药性和症状缓解不良。以邵经明等医师为代表的传统中医药长期以来一直依赖于针灸在穴位上,例如大椎、风门和肺俞,大大改善了哮喘患者的呼吸功能,并在七十年的实践中不断完善经验处方。

从实验室发现到临床潜力

杨永清教授的团队深入研究了针灸在哮喘治疗中的功效机制。针灸刺激多种靶标和生化反应,他们的研究利用小鼠哮喘模型,锁定了金属硫蛋白-2(MT-2)作为缓解哮喘症状的关键因子。此外,他们还证实了呼吸道中“双蛋白”的结合关系:上游的MT-2必须与下游的“作用受体”——肌动蛋白结合蛋白-2(Transgelin-2)结合。针灸的物理刺激促使这些蛋白结合,从而扩张气道和缓解哮喘症状。

引领哮喘治疗的未来

此外,他们的研究还发现了潜在的新型抗哮喘药物,俗称“针灸药”。论文的第一作者、上海中医药大学和上海市针灸经络研究所的博士尹磊淼表示,早在2003年,中国科学院上海药物研究所所长蒋华良和杨永清教授团队成立了“针灸中药效应联合实验室”,他们利用分子对接和虚拟筛选等技术,从6000个候选化合物中筛选出了具有特定靶标的分子化合物。

这些分子,具有与针灸相似的扩张支气管平滑肌的作用,有望成为新型抗哮喘药物。因此,杨永清的学术导师、上海市中医药研究院副院长陈汉平教授称之为“针灸药”,突显了它们从临床中医转化到实验室研究再回到临床实践的潜力。这项研究代表了中国首次独立的知识产权目标和新药物发现,强调了将传统中医与现代生物技术相结合的战略重要性。

开拓哮喘治疗的新途径

针对Transgelin-2受体的治疗为解决哮喘目前的挑战开辟了新的途径,正如《科学》的评论员所言。上海中医药大学科技实验中心副主任、市针灸所课题负责人王宇强调了这种方法在维护中国针灸研究领域。

Creative Ways to Keep Your Kids Active During Winter

The winter season often brings cold weather and shorter days, making it tempting to stay indoors and cozy up on the couch. However, it’s important to ensure that your kids stay physically active even during the winter months. The Center for Disease Control (CDC) recommends at least 1 hour of physical activity for kids every day to promote overall health and well-being. This article provides practical and interesting ways to help your children stay active during the winter season.

Indoor Exercise:

  1. Home Play: Engage in indoor activities that get the heart rate up. Walk the dog, play indoor races, or shovel the snow together.
  2. Creative Home Exercise: Make exercise fun by incorporating games. Play “rock, paper, scissors” with leg movements, do yoga sun salutations, or have stair races.
  3. Movement Breaks: Encourage movement breaks every hour. Incorporate jumping jacks, push-ups, sit-ups, and squats to keep energy levels up.
  4. Dance Challenges: Turn commercial breaks into dance contests. Use video games like Dance Dance Revolution for a fun and active experience.
  5. Basement Activities: Jump rope, do hula-hooping, or set up an indoor obstacle course in the basement.

Outdoor Exercise:

  1. Winter Sports: Take advantage of winter sports like sledding, skiing, and ice skating. Make them more exciting by trying variations like inner tube sledding or skating on natural frozen surfaces.
  2. Nature Exploration: Go for walks to watch the Northern Lights or explore nearby trails. Walk to places instead of driving to incorporate exercise into daily routines.
  3. Active Chores: Involve kids in outdoor chores like shoveling snow, raking leaves, or gardening.

Kids’ Exercise Programs:

  1. Traditional Classes: Enroll your children in traditional options such as sports leagues, gymnastics, dance classes, or YMCA programs.
  2. Variety of Options: Explore new opportunities like yoga, Zumba, wall climbing, in-line skating, skateboarding, and boot camps.
  3. Endurance Training: Consider programs that train kids for marathons, triathlons, and other endurance events.
  4. Parkour Gyms: Look for parkour gyms where kids can engage in obstacle-based training that blends running and acrobatics.

Keeping kids active during the winter is essential for their physical and mental well-being. Whether through indoor exercises, outdoor adventures, or structured programs, there are numerous ways to ensure that your children remain active and engaged during the colder months. By prioritising physical activity, you are helping them develop healthy habits that will benefit them in the long run. If you’re feeling lethargic or need support in staying motivated, consider seeking professional guidance to ensure you and your family stay active throughout the winter season.